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Heartworm Medication Part 2: Options to Fear-Based Recommendations

Updated: Feb 18, 2023

Written by Jan Rasmusen on June 16, 2009

If you haven’t read Part 1 of this article, “Heartworm Medication: Truths, Omissions and Profits,” please read it now unless you completely understand how and when heartworms are transmitted. Click the link at that article’s end to return here.

A Heartworm Society news release states: “By giving heartworm prevention every month, forgetful pet owners will have their pets protected when they need it most.” But doesn’t that also mean they get it when they need it least? Or need it not at all? Are you a “forgetful” owner?

In this part of my heartworm series, we’ll discusses informed decision-making, and suggests ways, if you want them, to limit or eliminate heartworm drugs. I am a researcher and holistic health advocate, not a vet. Please learn the facts then discuss with your vet the appropriate course given your dog’s location, lifestyle, travel schedule, health, climate and the time of year. Expect an open-mind and respect from your vet, or find another vet. Just as with vaccination, “one size fits all” is outdated, profit-driven, lazy medicine.

Take a look at the map above, courtesy of the Heartworm Society. Part 1 of this article demonstrated that transmission is heat and mosquito dependent. As expected, dark areas of the map, which show the most heartworm cases per clinic, are found in the hot, humid Southeastern US, especially the Atlantic and Gulf coasts and Mississippi Delta.

Don’t let the map scare you. If published seasonally, map colors would pale significantly during cool months. Also remember that you’re seeing generalities, not specifics. A clinic near a rural pond will likely have many cases while an urban clinic 15 miles away may have a much lower incidence. Maps are general. Determine your own microclimate. Ask your vet how many cases of heartworm infection he/she treated in the past year. Also ask if he/she treats all positive cases, or just those with advanced infestation. If the vet doesn’t keep detailed records, that should tell you something.

Conservative start/stop maps from heartworm researchers Drs. David Knight and James Lok (in “Seasonality of Heartworm Infections and Implications for Chemoprophylaxis”) show only two areas requiring year round heartworm meds: the southernmost areas of Florida and Texas. Houston, New Orleans and similar areas are shown requiring meds for 9 months. Other states range from 3-7 months. The Drs. wrote: “For nearly 80% of the states, the potential for heartworm transmission is limited to 6 months or less.”

The Heartworm Society warns that heartworm infestations are getting worse. DVM Magazine, a magazine for vets, reports that recent results do show a rise in the number of positive cases per clinic in 31 states. DMV reports: “The reasons likely are multifactorial, including increased heartworm testing, increased client base per clinic or even climate trends.”

Does Year Round Medicating Bring Extra Protection?

Applying suncreen at night is useless. So is taking heartworm medication when climate conditions prevent transmission. Only a small percentage of climes permit year-round transmission. Everyone else is unnecessarily subsidizing drug companies and “preventatives” sellers and, more importantly, exposing their dog to unnecessary risks.

Two exceptions: 1) “Forgetful” and irresponsible pet parents who won’t begin the medication on time or build their dog’s natural immunity might want to medicate year round, although that means they have to remember to give meds every month. 2) If your dog contracts heartworms within a few years of beginning medication … and you can show you gave meds year round … and your dog had the required blood tests (2 or 3), you may benefit a little financially because drug companies will pay for dog’s treatment. (Read the guarantee terms published by an on-line seller.)

Are Heartworm Preventatives Safe?

You’ve seen those scary photos of worm-strangled hearts, right? Shouldn’t you give meds year round just in case? Isn’t safe better than sorry?

But is that harmless little pill or yummie medical “brownie” really safe? No drug is completely free of risk and adverse reactions. I can find no long-term studies regarding cancer risks and organ damage for dogs receiving heartworm insecticides year round (or even for a few months). Such a study would be difficult to conduct and very expensive. Who would fund such a study — or publish any negative findings?

One clue to the possibility of adverse reactions should be label warnings: call your doctor immediately if ingested; keep away from children; wash your hands immediately after use…. How can medication be good for dogs but so dangerous for you?

Another question: is your dog healthy enough for these medications? The “Heartworm Prevention” page of the American Animal Hospital Association states: “Healthy kidneys and normal liver functions are essential in metabolizing most medications.” Many dogs, including my Jiggy, do not have healthy organ function. I wonder how many unhealthy animals are nevertheless on meds?

Adverse Reactions to Heartworm Medications

With any drug, study FDA and manufacturer information before medicating.

These adverse reactions have been reported to the FDA by manufacturers. (Click the links for more information; write or call manufacturers with any questions). Terms you might not understand include ataxia (gross lack of coordination of muscle movements), pruritus (itchy dermatologic condition), urticaria (hives), mydriasis (excessive pupil dilation), and erythema (skin redness). Other terms should be self-explanatory.

HEARTGARD and TriHeartPlus (ivermectin): Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia staggering, convulsions and hypersalivation. INTERCEPTOR (milbemycin oxime) reports the above reactions plus weakness. Sentinel (milbemycin oxime) reports vomiting, depression/lethargy, pruritus, urticaria, diarrhea, anorexia, skin congestion, ataxia, convulsions, hypersalivation and weakness.

REVOLUTION® (selamectin), Topical Parasiticide For Dogs and Cats: pre-approval reactions of vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors. Post-approval experience included the above plus pruritis, urticaria, erythema, ataxia, fever, and rare reports of death and seizures in dogs.

Proheart 6 : severe allergic reactions (anaphylaxis): facial swelling, itching, difficulty breathing, collapse; lethargy (sluggishness); not eating or losing interest in food; any change in activity level; seizures; vomiting and/or diarrhea (with and without blood); weight loss; pale gums, increased thirst or urination, weakness, bleeding, bruising; rare instances of death. This product was voluntarily withdrawn from the market in 2004 because of deaths but has been reintroduced. Read my post Heartworm Protection: Do We Need ProHeart 6?

For any other brand, research the product or its active ingredient before even thinking of administering it.

Also, never give any meds without first learning if any vitamins, minerals, herbal products or drugs interact negatively with the medication. Note age restrictions. Most importantly, learn what symptoms alert you to a reaction. Important note: Collies, Australian Shepards and related breeds have a sensitivity to ivermectin (Heartgard and others).

Beware any website or person professing the absolute safety of any medication. I’d like adverse reactions for pet medications to be included in all TV ads, as they are for meds for humans — but I don’t expect it.

Reporting Adverse Events: Call your veterinarian immediately if you suspect a reaction to this or any other drug. Discuss alternatives and treatment and make sure the reaction is recorded in your dog’s file. The AVMA says : “… notify the US Food and Drug Administration (FDA) by contacting the manufacturer. The FDA requires that manufacturers of FDA-approved drugs forward adverse event reports to the agency.” Is the fox is guarding the hen house? Ask your vet to report the reaction, then follow up and make sure your vet did it. Under-reporting is common. (An estimated 99% of adverse reactions go unreported according to the FDA.) Click here for FDA reporting instructions.

Tests for Heartworm Infection Heartworms can, and should, be detected by a simple blood test before administering medication. The antigen test detects an adult female worms at least 5-8 months old. The Merck Veterinary Manual says: “The antigen detection test is the preferred diagnostic method for asymptomatic dogs or when seeking verification of a suspected HW infection.”

Microfilariae (babies) in the blood are detected by a different blood test. These show exposure, but do not detect female adults (potential breeders). Antibody tests (as opposed to antigen tests) are not preferred because they indicate only that the dog has been exposed to heartworms at some time in his or her life, even if the worms subsequently died.

If you plan to give “preventatives,” test before beginning medication, preferably within a month of when daily temperatures consistently climb above 57˚ F. Read more at the Heartworm Society Serology section.

If you’re not going to use meds, homeopathic veterinarian Jeff Feinman wrote me that he advises semi-annual testing when not using preventatives. My own vet, Tamara Hebbler, agrees. Testing twice yearly helps you catch disease early when it’s easier to treat. Dr. Martin Goldstein in The Nature Of Animal Healing says: “Only a small percentage of dogs who get heartworm die of it, especially if they’re routinely tested twice yearly for early detection. Even in untreated dogs, after a period of uncomfortable symptoms, the adult worms die….”

Did you know that the latest canine movie star “Benji” was found in a shelter, infected with heartworms? Benji was treated successfully and went onto canine fame and a healthy life.

Heartworms, like other parasites, don’t become life threatening quickly or inevitably. It takes at least 5 months, and more often 7-8 months, for a baby to grow to a reproducing adult — presuming the dog’s immune system doesn’t intervene. Also, adult males and females must both survive to breed.

Important Note If your dog’s antigen test comes back positive, do a second test to verify results. Holistic vet Tamara Hebbler suggests that before you rush into treatment with harsh, poisonous drugs, you should get a cardiac ultrasound to determine the extent of the infestation. Heartworms, like other parasites, often live with their hosts without ever causing a dangerous problem. It’s quite common for animals in the wild to live entire lives with heartworms. (If worms always killed dogs, they’d soon run out of hosts.) Unless heartworms are re-introduced by another infected mosquito, the adults and their babies will eventually die off.

When Should You Start Administering Meds — If You’re Going To? Remember, you kill heartworm babies after the fact. You can only “prevent” them by avoiding mosquitoes. (You can also kill them with a healthy immune system.) This means starting meds 30-45 after the weather warms and mosquitoes appear. Also, Washington State University warns, “If your pet travels to heartworm areas, prevention needs to be administered within 30 days of exposure to infected mosquitoes. Adult dogs (older than 6 mos.) need to be tested before starting preventative.”

Dr. Margo Roman, an integrative vet from in Massachusetts, documentary film maker and Founder of the first-ever Integrative Health Pet Expo in Massachusetts this fall, tells me she begins medication six weeks after sees mosquitoes. This allows 2 weeks for the microfilariae (baby heartworms) to mature inside a mosquito to the infective stage and be transferred to a dog, plus 30 days additional days covered by the medication working backwards to kill those babies.

When Should You Stop Heartworm “Preventatives”?

Dr. Roman recommends stopping meds after the first frost for people living in an area with cold winters. In other areas, vets recommend stopping 30-45 days after weather is consistently below 57 F degrees and you see no mosquitoes. See Part 1 of this article, and the start/stop maps, for more details.

What Brand Should You Use?

Consumers often think that “preventing” as many parasites as possible with one product is a bargain — and ultimately safer for the dog. But why expose your dog to additional, unnecessary toxins? Most holistic vets will tell you to protect against only those pests (and diseases) your dog is likely to encounter. To see which products do what, see the “preventatives” comparison chart at Veterinary Partner.

***Low Dose “Safeheart” Medication Approved by the FDA

More than a decade ago — on June 4, 1998 — the FDA approved a 1/5 dose version of Interceptor heartworm medication, a product called Safeheart. This expensive field trial was conducted and the dosage approved — but inexplicably the product was never marketed in the U.S.

To duplicate the Safeheart heartworm “prevention” method — which you can’t buy — you have split the Interceptor dose into quarters. Check with Interceptor first, and ask your pharmacist or vet how to do this accurately. The recommended once-a-month dosage is 0.1 mg of milbemycin oxime per kg of body weight (0.05 mg/lb). (Interceptor’s regular dose of dosage is 0.5 mg milbemycin oxime per kg of body weight.) Print the FDA’s Safeheart report and take it to your vet for your prescription and additional instructions.

Note: At this dose, only heartworms will be treated with the Safeheart method, not other worms or fleas.

How Often Should You Give Meds?

In his important book Homeopathic Care For Cats and Dogs, veterinarian Don Hamilton says of heartworm: “In dogs the “monthly” preventives are effective if given at six week intervals, and possibly even at seven- or eight week intervals….” Author/veterinarians Richard Pitcairn and Allen Schoen told us essentially the same thing when we were researching our book Scared Poopless. If you opt for this “less is more” treatment with “preventatives,” mark dosing dates on your calendar and don’t miss them.

The vets at Holistic Vet Center say: “… monthly heartworm preventatives are actually 100% effective if given every 45 days and 99% effective if given every 60 days.”

I presume that the monthly schedule was designed for the ease of remembering when to give meds. However … giving meds monthly rather than every 45 days requires more doses — and offers more opportunities for adverse reactions. For someone medicating year-round, that’s 4 fewer doses per year.

Are There Natural Heartworm Preventatives?

Mosquito control is the ultimate natural preventative. No mosquitoes, no heartworms. Control mosquitoes by eliminating standing water and staying indoors at dusk and dawn. Use bug spray (marked safe and non-toxic for animals and children). Buy bug zappers. (All these are good ideas for human protection from mosquito-borne diseases as well.)

Is mosquito control 100% effective? No, but has some great tips. (Note: one study showed that a full moon increased mosquito activity by 500%.) Find more information on controlling mosquitoes in this University of California report.

What do I do? Well, for me, the choice was easy. I live in So. California. I rarely see mosquitoes. My dogs spend most of their time indoors. Nights are invariably cool.

With the advice of two local vets, I decided to protect my own dogs (both of whom have health challenges) against the toxicity of heartworm “preventatives” rather than protect against an unlikely infection. I use non-toxic alternatives like mosquito control, an excellent diet and no drugs unless they’re absolutely unavoidable. I increase safety by testing blood twice yearly. I haven’t used “preventatives” for five or six years and my dogs remain heartworm free. This is my personal decision. I am not a vet.

If I lived in a mosquito-heavy area, however, I might do much the same. I would determine local risks and would consult a local holistic vet to get help preventing heartworms naturally. I would control mosquitoes and test blood twice or more yearly. Someone who had “outside dogs,” and who was the nervous about heartworms, might also use heartworm meds or the Safeheart method during the peak heartworm months of July and August, but only if their dogs had healthy kidneys and livers. They should make any decision with a knowledgeable vet.

Dr. Will Falconer, a holistic vet certified in acupuncture and homeopathy, has written an e-book called “Drug-Free Heartworm Prevention.” This 50+ page, well-written e-book is delivered electronically. I do not profit from sales of this book although I was given a complementary review copy. Drs. Richard Pitcairn and Martin Goldstein have also written about heartworms in their books.

Please leave us a comment and let us know how you liked this article. Tell us about your concerns and decisions. If we have made any errors, please let us know so we can rectify them. And, please, tell your friends the facts behind heartworm transmission.

Most importantly, do not make decisions out of fear. Don’t let anyone, even your vet, intimidate or ridicule you. Be an educated consumer and a rabid advocate for your dog’s health.

Disclaimer: The information provided here is for educational purposes only. Do not rely on this information without doing your own research including consultation with your own veterinarian. Do not buy or fail a product for treating heartworm without evaluating it carefully.

There are reports of medication-resistant heartworm in the deep South region of the US. Read the article at

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